Both dengue and Zika viruses are members of the family Flaviviridae. Zika virus (ZIKV) is recently known for in utero transmission, causing microcephaly in newborns in the non-immune population 9. Targeting drugs towards viral replication protects the infected individuals from severe progression in the critical phase 8. Macrophages opsonize partially neutralized viruses, thus multiplying the viral replication and increasing severity 7. The secondary heterotypic infection misleads the immunological response towards the prior infection 5, 6. There are four serotypes of dengue virus (DENV1-4) with a minimum of 67% amino acid sequence identity among all DENV serotypes 4. Dengue has placed 2 billion people at risk every year and hospitalized about 500,000 people with severe hemorrhage, shock, and multiple organ failure 2, 3. Dengue, and Zika viruses share the same geographical niche as they are transmitted by the same mosquito, Aedes aegypti 1.
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